---
id: 39f6451e07
section: health
first_reported: 2026-11-07 14:23 EST
updated: 2026-11-07 14:23 EST
status: reported
outlets: 1
---

# Pelacarsen trial lowers Lp(a) but not cardiovascular events

A Cleveland Clinic-led trial found pelacarsen reduced Lp(a) levels by 78.4% but did not lower major cardiovascular events versus placebo over nearly five years.

Section: [Health](/cleveland/section/life.md) · Entities: [Cleveland Clinic](/cleveland/wiki/cleveland-clinic.md), [pelacarsen](/cleveland/wiki/pelacarsen.md)

## Coverage

- [cleveland.com / The Plain Dealer](https://www.cleveland.com/news/2026/11/cleveland-clinic-led-trial-finds-drug-lowered-lipoproteina-but-did-not-reduce-major-heart-events.html), 2026-11-07 14:23 EST: Major heart drug trial falls short of expectations

Headline and summary written by the Acta Diurna desk from the coverage above. Read the original reporting for full detail.